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Stories 1 - 10 for Protein kinases

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Poniard's Fortunes Likely Rest on Picoplatin

Genetic Engineering News (press release) - ‎Nov 25, 2009‎
The company licensed a class of protein kinase inhibitors for treating a variety of diseases from Scripps Research Institute. The candidates were discovered ...

Crosstalk Between Critical Cell-Signaling Pathways Holds Clues to Tumor ...

Science Daily (press release) - ‎Nov 25, 2009‎
The newly described pathway disrupts the beta-catenin/alpha catenin complex through an EGFR-extracellular receptor kinase (ERK)-protein kinase CK2- ...

Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast ...

7thSpace Interactive (press release) - ‎Nov 25, 2009‎
We have previously shown that Matrix metalloproteinase (MMP) -2 is a key-enzyme in early trophoblast invasion and that Protein Kinase A (PKA) increases ...

Developments in Focused Kinase Libraries

Genetic Engineering News (press release) - Richard Hill - ‎Nov 16, 2009‎
Protein kinases are enzymes that phosphorylate substrate proteins at specified residues such as serine, threonine, and tyrosine. The phosphorylation of the ...

Enzyme block reduces death in mice with myotonic dystrophy

The Cherokeean Herald - ‎Nov 10, 2009‎
10, 2009) – Using drugs to block the action of an enzyme called protein kinase C can reduce or even eliminate heart problems in mice with myotonic dystrophy ...

Collaborative team wins $1 million for drug research

Lifescience Lab - ‎Nov 16, 2009‎
Kinomics is the detailed study of kinases. About 2% of the human genome appears to encode at least 515 protein kinases. Pharmaceutical companies are ...

Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice ...

7thSpace Interactive (press release) - ‎Nov 13, 2009‎
Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is ...

Abnormalities in brain structure and behavior in GSK-3 mutant mice

7thSpace Interactive (press release) - ‎Nov 19, 2009‎
Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related ...

Myriad Pharmaceuticals Confirms That MPC-3100, a Fully-Synthetic Hsp90 ...

CNNMoney.com (press release) - ‎Nov 16, 2009‎
Important client proteins in cancer cells include steroid hormone receptors, protein kinases, mutant p53, and telomerase. Hsp90 binds and stabilizes these ...

New schizophrenia therapy research from Technion, Department of Pharmacology ...

Behavioral Health Central (blog) - ‎Nov 23, 2009‎
There are modifications in gamma-aminobutyric acid system via glutamate decarboxylase 67, protein kinase C beta and the receptor for activated C-kinase 1 ...
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